Power comparisons between similarity-based multilocus association methods, logistic regression, and score tests for haplotypes
نویسندگان
چکیده
منابع مشابه
Robust tests of association for multilocus haplotypes in nuclear families
Genetic epidemiology relies heavily on tests of association between genetic variants and disease outcomes or quantitative traits. Associations imply either that a genetic variant has a direct causal influence on the trait, or that the variant is a marker that is physically close on a chromosome to a causal variant. Despite the popularity of association tests, there is a wide and sometimes confu...
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Association tests of multilocus haplotypes are of interest both in linkage disequilibrium mapping and in candidate gene studies. For case-parent trios, I discuss the extension of existing multilocus methods to include ambiguous haplotypes in tests of models which distinguish between the cis and trans phase. A likelihood-ratio test is proposed, using the expectation-maximization (E-M) algorithm ...
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In association tests of sites with low minor allele frequency or count, it is known that single-variant tests are impractical to use because the results from which will be either underpowered or unreliable. Joint analyses by pooling or “collapsing” multiple variants based on annotated gene group information are thus more preferred in rare variant association tests. However, the issue remains in...
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To detect genetic association with common and complex diseases, many statistical tests have been proposed for candidate gene or genome-wide association studies with the case-control design. Due to linkage disequilibrium (LD), multi-marker association tests can gain power over single-marker tests with a Bonferroni multiple testing adjustment. Among many existing multi-marker association tests, m...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2009
ISSN: 0741-0395,1098-2272
DOI: 10.1002/gepi.20364